GIST and mast cell tumor require the PI3K-Akt pathway on intracellular compartments for their proliferation ~Oncogenic Kit signaling occurs selectively on the Golgi and endo/lysosomes~

Yuuki Obata; Keita Horikawa; Tsuyoshi Takahashi; Yuki Akieda; Masahiko Tsujimoto; Yasushi Hara; Hiroyasu Esumi; Toshirou Nishida; Ryo Abe

[3P-0376(3PS7-4)] GIST and mast cell tumor require the PI3K-Akt pathway on intracellular compartments for their proliferation ~Oncogenic Kit signaling occurs selectively on the Golgi and endo/lysosomes~

〇Yuuki Obata¹, Keita Horikawa¹, Tsuyoshi Takahashi³, Yuki Akieda¹, Masahiko Tsujimoto⁴, Yasushi Hara¹, Hiroyasu Esumi², Toshirou Nishida⁵, Ryo Abe¹ (1.Div. of Immunobiol., RIBS, Tokyo Univ. of Sci., 2.Div. of Clin. Res., RIBS, Tokyo Univ. of Sci., 3.Dep. of Surgery, Grad. Sch. of Med., Osaka Univ., 4.Osaka Police Hospital, 5.NCC Hospital)

PI3K-Akt, オルガネラ, がんシグナリング, Kitチロシンキナーゼ, 異常局在

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The 39th Annual Meeting of the Molecular Biology Society of Japan

[3P-0376(3PS7-4)] GIST and mast cell tumor require the PI3K-Akt pathway on intracellular compartments for their proliferation ~Oncogenic Kit signaling occurs selectively on the Golgi and endo/lysosomes~

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