The Molecular Biology Society of Japan

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[3PS7-4(3P-0376)] GIST and mast cell tumor require the PI3K-Akt pathway on intracellular compartments for their proliferation ~Oncogenic Kit signaling occurs selectively on the Golgi and endo/lysosomes~

〇Yuuki Obata1, Keita Horikawa1, Tsuyoshi Takahashi3, Yuki Akieda1, Masahiko Tsujimoto4, Yasushi Hara1, Hiroyasu Esumi2, Toshirou Nishida5, Ryo Abe1 (1.Div. of Immunobiol., RIBS, Tokyo Univ. of Sci., 2.Div. of Clin. Res., RIBS, Tokyo Univ. of Sci., 3.Dep. of Surgery, Grad. Sch. of Med., Osaka Univ., 4.Osaka Police Hospital, 5.NCC Hospital)

PI3K-Akt, オルガネラ, がんシグナリング, Kitチロシンキナーゼ, 異常局在

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