[1P-0642] Roles of GPNMB in Breast Cancer Stem Cells

〇Chen Chen¹, Yukari Okita¹, Mitsuyasu Kato¹ (1.Laboratory of Experimental Pathology, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0643(1PS13-3)] SReg1 decides the fate of hematopoietic stem cell

〇Hiroyasu Kidoya¹, Fumitaka Muramatsu¹, Weizhen Jia¹, Yumiko Hayashi¹, Nobuyuki Takakura¹ (1.Dept. signal Transduction., RIMD, Osaka Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0644] Deciphering the function of KLF4 as a differentiation inducer in haematologic malignancies

〇Hiroki Kiyose¹, Ken Morita¹, Shintaro Maeda¹, Kensyo Suzuki¹, Chieko Tokushige¹, Yoshimi Yamada¹, Soichi Adachi¹, Yasuhiko Kamikubo¹ (1.Dept. of Hum. Health Sci., Grad Sch., Kyoto Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0645] NDRG2 down-regulation induces hypoxic resistance via activation of PI3K/AKT signaling in ATLL

〇Shingo Nakahata¹, Tomonaga Ichikawa¹, Yusuke Saito¹, Tomohiko Taki², Masafumi Taniwaki³, Kazuhiro Morishita¹ (1.Div. Tumor&Cell. Biochem., Dept. Med. Sci., Miyazaki Univ., 2.Dept. Mol. Lab. Med., Kyoto Pref. Univ. of Med., 3.Dept. Hematol.&Oncol., Kyoto Pref. Univ. of Med.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0646] Comprehensive profiling of HTLV–1 infected cells based on mutation and integration site data coupled with phenotypic analysis of ATL progression.

〇Sanaz Firouzi¹, Amir Farmanbar^1,2, Sarun Ball Sereewattanawoot¹, Seiichiro Kobayashi³, Kenta Nakai^1,2, Toshiki Watanabe^1,4, Yutaka Suzuki¹, Kaoru Uchimaru^1,3 (1.Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 2.Laboratory of Functional Analysis in silico, Human Genome Center, The Institute of Medical Science, The University of Tokyo, 3.Hematology/Oncology, Research Hospital, the Institute of Medical Sciences, The University of Tokyo, 4.Institute of Medical Science and Departments of Immunology and Medicine, St. Marianna University School of Medicine)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0647] Functional analysis of UTX, a demethylase for histone H3K27, in normal hematopoiesis and leukemogenesis.

〇Yasuyuki Sera¹, Takeshi Ueda², Yu-ichiro Nakata¹, Ken-ichiro Ikeda¹, Norimasa Yamasaki¹, Hideaki Oda³, Akiko Nagamachi⁴, Akinori Kanai⁴, Toshio Suda⁵, Keiyo Takubo⁶, Hiroaki Honda¹ (1.Dept. of Ddisease Model, Res. Inst. for Radiation Biol. and Medi., Univ. of Hiroshima, 2.Dept. of Biochem., Fac. of Med., Univ. of Kinki, 3.Dept. of Pathology, Grad. Sch. of Med., Tokyo Women's Medical Univ., 4.Dept. of Mol. Oncology and Leukemia Program Project, Res. Inst. for Radiation Biol. and Medi., Univ. of Hiroshima, 5.Canc. Sci. Inst., Natl. Univ. of Singapore, 6.Dept. of Stem Cell Biol., Res. Inst. Natl. Ctr. for Global Hlth. and Med.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0648] Heterozygous Dnmt3a mutation induces expansion of hematopoietic stem cell pool in a murine model

〇Takashi Higo¹, Junji Koya¹, Yoshiki Sumitomo^1,2, Takako Tsuruta¹, Keisuke Kataoka¹, Tomohiko Satou¹, Mineo Kurokawa^1,3 (1.Dept. of Hematol. Grad.Sch. of Med., Univ. of Tokyo, 2.Oncol. Lab., Kyowa Hakko Kirin Co., Ltd., 3.Dept. of Cell Therapy and Transplantation, Univ. of Tokyo Hospital)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0649] LSD1 acts at the initial step of leukemogenesis to form pre-leukemic hematopoietic stem cells.

〇Taeko Wada¹, Daisuke Koyama¹, Jiro Kikuchi¹, Hiroaki Honda², Yusuke Furukawa¹ (1.Div. of Stem Cell Regilation, Center for Mol. Med., Jichi Med. Univ., 2.Dept. of Disease Model, Research Institute for Radiation Biology and Medicine, Hiroshima Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0650] Effects of mutant IDH producing D-2-HG on the differentiation property and transformation of mesenchymal stem cells.

〇Takeshi Kamakura^1,2, Yonghui Jin^1,3, Makoto Watanabe^2,4, Kazuhito Matsunaga^2,5, Sakura Tamaki^1,2, Takeshi Okamoto⁶, Hiroyuki Yoshitomi^1,2, Junya Toguchida^1,2,6 (1.Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan, 2.Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan, 3.Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan, 4.Life Science Research Center, Shimadzu Coopration, Kyoto, Japan, 5.Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan., 6.Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0651] Nuclear export of lysine-specific dimethylase 1 induced by geranylgeranoic acid treatment in human hepatoma cells.

〇Suemi Yabuta¹, Yoshihiro Shidoji¹ (1.Mol Cell Biol, Grad Sch of Human Health Sci., Univ of Nagasaki)

The 39th Annual Meeting of the Molecular Biology Society of Japan