The Molecular Biology Society of Japan

[1LBA-003] Paradoxical repeat sequence destabilisation in human cells with deleterious MSH2 mutations introduced by genome editing

〇Shinya Oda1, Genki Hayashida2,6, Kyoko Hidaka3, Ryosuke Fujikane4, Masumi Hidaka4, Teruhisa Tsuzuki5, Yoshimichi Nakatsu6 (1.Clin. Res. Inst., Natl. Kyushu Cancer Ctr., 2.Grad. Sch. Syst. Life. Sci., Kyushu.Univ, 3.Ctr. Fundam. Ed., Kitakyushu Univ, 4.Dept. Phys. Sci. Mol. Biol., Fukuoka Dent. Coll., 5.Adv. Sci. Res. Ctr., Fukuoka Dent. Coll., 6.Dept. Med. Biophys. Radiat. Biol., Fac. Med., Kyushu Univ.)

CRISPR/Cas9, DNA mismatch repair, Lynch syndrome, genomic instability, microsatellites

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