The Molecular Biology Society of Japan

[1LBA-112] The trans isomer of Tau peptide is prone to aggregate, and WW domain of Pin1 drastically decreases its aggregation

〇Teikichi Ikura1, Naoya Tochio2,3, Ryosuke Kawasaki4, Mizuki Matsuzaki5, Akihiro Narita5, Mahito Kikumoto5, Naoko Utsunomiya Tate3, Shin-ichi Tate2,4, Nobutoshi Ito1 (1.Med Res Inst, Tokyo Med & Dent Univ, 2.RcMcD, Hiroshima Univ, 3.Fac of Pharm-Sci, Teikyo Univ, 4.Dept of Math & Life Sci, Grad Sch of Sci, Hiroshima Univ, 5.Struct Biol Res Center, Grad Sch of Sci, Nagoya Univ)

Pin1, WW domain, Tau protein, neurofibrillary tangles, Alzheimer's disease

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