Elucidation of structural mechanism for inhibition of a voltage-gated potassium ion channel, hERG1, by a gating modifier toxin, APETx1.

Kazuki Matsumura; Masahiro Fukuda; Naomi Yanase; Madoka Akimoto; Nanami Iwasaki; Kazuho Sakamoto; Junko Kurokawa; Mariko Yokogawa; Masanori Osawa

[1P-0042] Elucidation of structural mechanism for inhibition of a voltage-gated potassium ion channel, hERG1, by a gating modifier toxin, APETx1.

〇Kazuki Matsumura¹, Masahiro Fukuda¹, Naomi Yanase¹, Madoka Akimoto¹, Nanami Iwasaki², Kazuho Sakamoto², Junko Kurokawa², Mariko Yokogawa¹, Masanori Osawa¹ (1.Keio Univ. Grad. Sch. Pharm. Sci., 2.Univ. of Shizuoka Sch. Pharm. Sci.)

Voltage-gated potassium ion channel, hERG1, Voltage sensing domain, APETx1, Structural analysis

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The 41st Annual Meeting of the Molecular Biology Society of Japan

[1P-0042] Elucidation of structural mechanism for inhibition of a voltage-gated potassium ion channel, hERG1, by a gating modifier toxin, APETx1.

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