The Molecular Biology Society of Japan

[1P-0529] Establishment of a cell line bearing the same mutation of the MECP2 gene as in the patient using the CRISPR/Cas9 system.

〇Kenji Orimoto1, Toyjiro Matsuishi 2, Kotaro Yuge 3, Shin-ichi Horike4, Makiko Meguro4 (1.Dept of Gen Int Med, Fureai Higashi-Totsuka Hosp, 2.Res Ctr for Ch, Res Ctr for RTT, St Mary’s Hosp, 3.Dept of Pediatr, Sch of Med, Univ of Kurume, 4.Div of Functional Genomics, Adv Sci Res Ctr, Univ of Kanazawa)

Rett syndrome, MECP2 C-terminal deletion, CRSPR/Cas9 system, mTOR, mir199

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