[1P-0666] Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury through the inhibition of S6K1 phosphorylation

〇Da Hyun Lee^1,2, Buhyun Lee^1,2, Jeong Su Park², Yu Seol Lee^1,2, Jin Hee Kim⁶, Yejin Cho², Yoonjung Jo³, Hyun-Seok Kim³, Yong-ho Lee^4,5, Ki Taek Nam^1,2, Soo Han Bae² (1.Brain Korea 21 PLUS Project for Medical Science, Yonsei University, 2.Severance Biomedical Science Institute, Yonsei Biomedical Research Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea, 3.Department of Bioinspired Science, Ewha Womans University, Seoul 120-750, Korea, 4.Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea, 5.Institute of Endocrine Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea, 6.Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea)

Sirtuin2, Acetaminophen, ER stress, S6K1, Hepatotoxicity