[1P-0666] Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury through the inhibition of S6K1 phosphorylation

〇Da Hyun Lee^1,2、Buhyun Lee^1,2、Jeong Su Park²、Yu Seol Lee^1,2、Jin Hee Kim⁶、Yejin Cho²、Yoonjung Jo³、Hyun-Seok Kim³、Yong-ho Lee^4,5、Ki Taek Nam^1,2、Soo Han Bae² (1.Brain Korea 21 PLUS Project for Medical Science, Yonsei University、2.Severance Biomedical Science Institute, Yonsei Biomedical Research Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea、3.Department of Bioinspired Science, Ewha Womans University, Seoul 120-750, Korea、4.Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea、5.Institute of Endocrine Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea、6.Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea)

Sirtuin2, Acetaminophen, ER stress, S6K1, Hepatotoxicity