The Molecular Biology Society of Japan

[1P-0768] Development of a novel protein-knockdown strategy to bring targeted protein and arylhydrocarbon receptor (AhR) E3 ligase into close proximity.

〇Nobumichi Ohoka1, Genichiro Tsuji2, Takuji Shoda2, Takuma Fujisato2, Yosuke Demizu2, Mikihiko Naito1 (1.Div. of Mol. Target & Gene Thera. Pro., NIHS, 2.Div. of Org. Chem., NIHS)

targeted protein degradation, ubiquitin, E3 ligase, SNIPER, PROTAC

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