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[2AW-09-1(2P-0611)] Identification of the synthetic lethal gene under the condition of PARG dysfunction and analysis of cell death mechanisms

〇Yuka Sasaki1,2, Hiroaki Fujimori3, Miyuki Hozumi3,4, Takae Onodera1,2, Yasufumi Murakami4, Fumiaki Koizumi5,1, Kengo Inoue6, Mitsuko Masutani1,2 (1.Dept. Frontier Life Sci., Grad. Sch. Biomed. Sci., Nagasaki Univ., 2.Lab of Collaborative Research, Div. Cell Signaling, Natl. Cancer Ctr. Res. Inst., 3.Div. Chemother. and Clin. Res., Natl. Cancer Ctr. Res. Inst., 4.Tokyo Univ. Sci., Fac. Indus. Sci. Tech., 5.Div. Clin. Res. Support, Komagome Hosp., 6.Pharma Valley Center)

poly(ADP-ribosyl)ation, PARG, synthesic lehtality, poly (ADP-ribose), anti-cancer agent

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