The Molecular Biology Society of Japan

[2P-0441] AKT signaling promotes epigenetic reprogramming through transcriptional and metabolic shift during iPSC generation.

〇Yoichi Sekita1, Yuki Sugiura2, Akari Matsumoto1, Yuki Kawasaki3, Toshiaki Ito1, Kazuya Akasaka1, Terushi Yamazaki1, Ryo Konno4, Toshinobu Nakamura5, Fumitoshi Ishino3, Yoshio Kodera4, Takashi Kohda3,6, Tohru Kimura1 (1.Lab of Stem Cell Biol, Depart of Biosci, Kitasato Univ Schl of Science, 2.Dept of Biochem & Integrative Med Biol, Schl of Medicine, Keio Univ, 3.Dept of Epigenetics, MRI, TMDU, 4.Lab of Biomol Physics, Depart of Physics, Kitasato Univ Schl of Science, 5.Lab for Epigenetic Regulation, Nagahama Inst of Bio-Science & Technol, 6.Lab of Embryology & Genomics, Dept of Biotechnol, Faculty of Life and Environmental Sci, Univ of Yamanashi)

iPS cell, Akt, Epigenetics, Metabolism, Tet

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