[3P-0130] Additional dose-dependent reductionsof H3K27me3 levels repress cell proliferation in Eed-mutated leukemia cells.

〇Yuichiro Nakata¹, Takeshi Ueda², Kenichiro Ikeda¹, Akinori Kanai³, Hiroaki Honda¹ (1.Department of Disease Model, Research Institute for Radiation Biology and Medicine, Hiroshima University, 2.Department of Biochemistry, Faculty of Medicine, Kindai University, 3.Department of Molecular Oncology, Research Institute of Radiation Biology and Medicine, Hiroshima University)

epigenetics, leukemia, PRC2, synthetic lethality, siRNA library