The Molecular Biology Society of Japan

[3P-0130] Additional dose-dependent reductionsof H3K27me3 levels repress cell proliferation in Eed-mutated leukemia cells.

〇Yuichiro Nakata1, Takeshi Ueda2, Kenichiro Ikeda1, Akinori Kanai3, Hiroaki Honda1 (1.Department of Disease Model, Research Institute for Radiation Biology and Medicine, Hiroshima University, 2.Department of Biochemistry, Faculty of Medicine, Kindai University, 3.Department of Molecular Oncology, Research Institute of Radiation Biology and Medicine, Hiroshima University)

epigenetics, leukemia, PRC2, synthetic lethality, siRNA library

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