[3P-0262] Cell detachment and ligand dissociation capability of integrin αsubunit blocking mAb is dependent on epitopes and suggests allosteric mode of action.

〇Mikage Otani¹, Norihisa Nishimichi², Masumi Ito², Masao Yoshizumi⁴, Yasuyuki Yokosaki^3,2 (1.Cell-matrix Lab., Grad. Sch. of Med., Univ. of Hiroshima, 2.Cell-matrix Lab., Health Admin., Hiroshima Univ., 3.Clin. Gene., Hiroshima Univ. Hosp., 4.Dept. Of Cardiovasc physiol and Med., Grad. Sch. of Med., Univ. of Hiroshima)

integrin, antibody, mode of action