The Molecular Biology Society of Japan

[3P-0262] Cell detachment and ligand dissociation capability of integrin αsubunit blocking mAb is dependent on epitopes and suggests allosteric mode of action.

〇Mikage Otani1, Norihisa Nishimichi2, Masumi Ito2, Masao Yoshizumi4, Yasuyuki Yokosaki3,2 (1.Cell-matrix Lab., Grad. Sch. of Med., Univ. of Hiroshima, 2.Cell-matrix Lab., Health Admin., Hiroshima Univ., 3.Clin. Gene., Hiroshima Univ. Hosp., 4.Dept. Of Cardiovasc physiol and Med., Grad. Sch. of Med., Univ. of Hiroshima)

integrin, antibody, mode of action

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