3:49 PM - 4:01 PM

[3PW-13-1] XRCC1 inhibits the cytotoxic effect of the stable PARP-DNA complex during base-excision repair

〇Kouji Hirota¹, Masataka Tsuda^2,3, Masato Ooka^2,1, Shimizu Naoto², Tetsushi Sakuma³, Takashi Yamamoto³, Shunishi Takeda² (1.Department of Chemistry, Tokyo Metropolitan University, 2.Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 3.Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University)

Base-Excision Repair (BER), Olaparib, PARP inhibitor, single strand break repair(SSBR), XRCC1