5:01 PM - 5:13 PM

[3PW-13-7] BRCA1 ensures genome integrity by eliminating estrogen-induced pathological Topoisomerase II-DNA complexes

〇Hiroyuki Sasanuma¹, Masataka Tsuda^1,6, Suguru Morimoto¹, Junji Itou³, Masakazu Toi³, Shinichiro Nakada⁵, Ken Tsutsui⁴, Andre Nussenzweig², Takeda Shunichi¹ (1.Department of radiation genetics, Graduate school of medicine, Kyoto university, 2.NIH, 3.Department of breast surgery, Graduate school of medicine, Kyoto university, 4.Graduate School of Medicine, Okayama university, 5.Department of Bioregulation and Cellular Response, Institute for Advanced Co-Creation Studies, Osaka University, 6.Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University)

DNA double-strand breaks, BRCA1, Estrogen, Mre11