The Molecular Biology Society of Japan

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[3PW-13-7] BRCA1 ensures genome integrity by eliminating estrogen-induced pathological Topoisomerase II-DNA complexes

〇Hiroyuki Sasanuma1, Masataka Tsuda1,6, Suguru Morimoto1, Junji Itou3, Masakazu Toi3, Shinichiro Nakada5, Ken Tsutsui4, Andre Nussenzweig2, Takeda Shunichi1 (1.Department of radiation genetics, Graduate school of medicine, Kyoto university, 2.NIH, 3.Department of breast surgery, Graduate school of medicine, Kyoto university, 4.Graduate School of Medicine, Okayama university, 5.Department of Bioregulation and Cellular Response, Institute for Advanced Co-Creation Studies, Osaka University, 6.Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University)

DNA double-strand breaks, BRCA1, Estrogen, Mre11

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