Identification of novel molecular glue that induces selective degradation of splicing factor CAPER-alpha via CUL4-DCAF15 ubiquitin ligase

Taisuke Uehara; Yukinori Minoshima; Koji Sagane; Naoko Sugi; Kaoru Mitsuhashi; Noboru Yamamoto; Hiroshi Kamiyama; Kentaro Takahashi; Yoshihiko Kotake; Mai Uesugi; Akira Yokoi; Atsushi Inoue; Miyuki Mabuchi; Akito Tanaka; Takashi Owa

9:19 AM - 9:44 AM

[1AS-01-2] Identification of novel molecular glue that induces selective degradation of splicing factor CAPER-alpha via CUL4-DCAF15 ubiquitin ligase

〇Taisuke Uehara¹, Yukinori Minoshima¹, Koji Sagane¹, Naoko Sugi¹, Kaoru Mitsuhashi¹, Noboru Yamamoto¹, Hiroshi Kamiyama¹, Kentaro Takahashi¹, Yoshihiko Kotake¹, Mai Uesugi¹, Akira Yokoi¹, Atsushi Inoue¹, Miyuki Mabuchi², Akito Tanaka², Takashi Owa¹ (1.Eisai Co., Ltd., 2.School of Pharmacy, Hyogo University of Health Science)

splicing, ubiquitin, protein degradation, molecular glue, DCAF

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The 42nd Annual Meeting of the Molecular Biology Society of Japan

[1AS-01-2] Identification of novel molecular glue that induces selective degradation of splicing factor CAPER-alpha via CUL4-DCAF15 ubiquitin ligase

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