[1LBA-017] Impaired ligand‐dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer

〇Yumiko Tahira^1,2, Wenyu Miao¹, Katsuya Sakai^1,2, Hiroki Sato ², Ryu Imamura^1,2, Nawaphat Jangphattananont¹, Kunio Matsumoto^1,2,3 (1.Div. of Tumor Dynamics & Regulation, Cancer Research Inst., Univ. of Kanazawa, 2.Nano Life Science Inst. (WPI-NanoLSI), Univ of Kanazawa, 3.Inst. for Frontier Science Initiative, Univ. of Kanazawa)

MET receptor, affinity, hepatocyte growth factor, loss of function, missense mutation