[1P-0404] Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells

〇Yusuke Sakai¹, Hidetoshi Kassai¹, Hisako Nakayama^2,5,6, Masahiro Fukaya³, Tatsuya Maeda^4,7, Kazuki Nakao¹, Kouichi Hashimoto², Hiroyuki Sakagami³, Masanobu Kano⁵, Atsu Aiba¹ (1.Lab. of Anim. Resources., Grad. Sch. of Med., Univ. of Tokyo, 2.Dept. of Neurophysiol., Grad. Sch. of Biomed and Health Sci., Hiroshima Univ., 3.Dept. of Anat., Sch. of Med., Kitasato Univ., 4.Inst. of Mol. and Cel. Biosci., Univ. of Tokyo, 5.Dept. of Neurophysiol., Grad. Sch. of Med., Univ. of Tokyo, 6.Dept. of physiol., Sch. of Med., Tokyo Women's Med. Univ., 7.Dept. of Biol., Hamamatsu Univ.)

Cerebellum, Purkinje cell, mTOR, Transgenic mice, Apoptosis