[1P-0510] Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes

〇Chisato Inoue¹, Sayaka Sobue¹, Naoki Mizutani¹, Yoshiyuki Kawamoto¹, Yuji Nishizawa¹, Masatoshi Ichihara¹, Toshiyuki Takeuchi², Fumihiko Hayakawa³, Motoshi Suzuki², Tetsuro Ito⁴, Yoshinori Nozawa⁵, Takashi Murate¹ (1.Dept. of Biomed. Sci., Coll. of Life Health Sci., Chubu Univ., 2.Dept. of Mol. Oncol., Sch. of Med., Fujita Health Univ., 3.Dept. of Haematol. and Oncol., Grad. Sch. of Med., Nagoya Univ., 4.Gifu Pharmaceutical Univ., 5.Dept. of Netrit. Sci., Coll. of Physic. Ther., Tokai Gakuin Univ.)

vaticanol C, apoptosis, sphingolipid rheostat, SPHK, GCS