[1P-0615] Application of human/mouse artificial chromosome technology (14) : Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism

〇Satoshi Abe^1,2, Kaoru Kobayashi³, Masumi Hirabayashi^4,5, Naoyo Kajitani¹, Kanako Kazuki¹, Jiro Kuze^1,6, Tetsushi Sakuma⁷, Takehito Kaneko^8,9, Tomoji Mashimo^9,10, Ryoichi Fujiwara¹¹, Yasuko Tsukazaki¹², Naoto Senda¹², Takashi Yamamoto⁷, Mitsuo Oshimura^1,2, Yasuhiro Kazuki^1,13 (1.CERC, Tottori Univ., 2.Trans Chromosomics Inc., 3.Grad. Sch. of Phrma. Sci., Chiba Univ., 4.Natl. Inst. for Pysiol. Sci., 5.Dept. of Physiol. Sci., Sch. of Life Sci., SOKENDAI, 6.Taiho Pharma. Co., Ltd., 7.Div. of Integr. Sci. for Life, Grad. Sch. of Integr. Sci. for Life, Hiroshima Univ., 8.Div. of Sci. & Eng., Grad. Sch. of Arts & Sci., Iwate Univ., 9.Inst. of Lab. Anim., Grad. Sch. of Med., Kyoto Univ., 10.Inst. of Exp. Anim. Sci., Grad. Sch. of Med., Osaka Univ., 11.Sch. of Pharm., Kitasato Univ., 12.Tsukuba Bioanal. Lab., Shin Nippon Biomed. Lab., Ltd., 13.Dept. of Biomed. Sci., Grad. Sch. of Med. Sci., Tottori Univ.)

ヒト化モデル動物, マウス人工染色体, 染色体移入, ゲノム編集, トランスクロモソミックラット