[2LBA-105] Wnt inhibition facilitates RNA-mediated reprogramming of human somatic cells to naive pluripotency

〇Ge Guo¹, Nicholas Bredenkamp¹, Jian Yang^1,3,7, James Clarke¹, Giuliano Giuseppe Stirparo¹, Ferdinand von Meyenn^4,5, Sabine Diemann¹, Duncan Baker⁶, Rosalind Drummond¹, Yongming Ren⁸, Dongwei Li³, Chuman Wu³, Maria Rostovskaya¹, Sarah Eminli-Meissner⁸, Austin Smith^1,2 (1.Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, United Kingdom, 2.Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, United Kingdom, 3.Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China, 510530, 4.Department of Medical & Molecular Genetics, King's College London, London SE1 9RT, United Kingdom, 5.Institute of Food, Nutrition and Health, ETH Zurich, 8603 Schwerzenbach, Switzerland, 6.Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom, 7.Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China, 8.REPROCELL USA, 9000 Virginia Manor Rd #207, Beltsville, MD 20705, USA)

human naive iPSC, reprogramming, Wnt inhibition