[2P-0262] A novel specific inhibitor of SMG1 reveals a signaling pathway regulated by SMG1-NRF2 upon oxidative stress.

〇Yumiko Fujikawa¹, Akio Yamashita¹, Tetsuo Ohnuki³, Kae Suzuki¹, Kyoko Aoyagi¹, Hitomi Kurosawa¹, Hiroko Hirose¹, Yoko Nagai¹, Hiroji Uemura², Minoru Yoshida³, Hidehisa Takahashi¹, Shigeo Ohno¹ (1.Dept. of Mol. Biol., Grad. Sch. of Med., Yokohama City Univ., 2.Yokohama City Univ. Med. Center, 3.Chem. Genet. Lab., RIKEN)

PIKKs, SMG1, NRF2, Oxidative stress, Specific inhibitor