[2P-0441(2AW-06-7)] CHCHD2 mutations cause TDP-43/TBPH misdistribution and exacerbate mitochondrial dysfunction

〇Hongrui Meng¹, Tsuyoshi Inoshita², Kahori Shiba-Fukushima², Kenya Nishioka⁴, Manabu Funayama³, Yuzuru Imai^4,5, Nobutaka Hattori^1,2,3,4 (1.Dept Neurodegenerative and Demented Disorders, Juntendo Univ. Tokyo, 2.Dept Treatment and Rsearch in Multiple Sceroses and Neuro-intractable Disease, Juntendo Univ. Tokyo, 3.Research Institute for Diseases of Old Age, Juntendo Univ. Tokyo, 4.Department of Neurology, Juntendo Univ. Tokyo, 5.Department of Research for Parkinson's Disease, Juntendo Univ. Tokyo)

mitochondria, TDP-43