[2P-0598] The molecular basis to clarify the pathogenesis of a rare skeletal disease, MCTO -Shifting from Knock-out to Disease specific-

〇Yuki Tsunakawa¹, Masahiro Shinohara¹, Michito Hamada², Hyjeong Jeon², Seiya Mizuno⁶, Zankl Andreas⁹, Toshiaki Usui^2,5, Sayaka Fuseya^2,4, Maho Kanai^2,3, Naoki Morito^2,5, Satoru Takahashi^2,6,7,8 (1.Mol Pathol. Sect., Dept. of Mvt., NRCD, 2.Dept. of Ana. Emb., Faculty of Med., Univ. of Tsukuba, 3.HBP, SIGMA, Univ. of Tsukuba, 4.Majors of Med Sci., Grad. Sch. of Comp Hmn Sci., Univ. of Tsukuba, 5.Dept. of nephrol., Faculty of Med., Univ. of Tsukuba, 6.ARC., Univ. of Tsukuba, 7.IIIS., Univ. of Tsukuba, 8.TARA., Univ. of Tsukuba, 9.Bone Bio Div, Garvan Inst. Med, Aus)

MafB, Multicentric Carpal Tarsal Osteolysis, Focal Segmental Glomerulosclerosis, Disease specific models