[3P-0435] Neural stem cell specific ITPA deficiency causes depolarization of neurons, resulting in epileptic seizure and early death in mice

〇Daisuke Tsuchimoto¹, Yuichiro Koga¹, Yoshinori Hayashi^2,3, Nona Abolhassani¹, Yasuto Yoneshima¹, Kunihiko Sakumi¹, Hiroshi Nakanishi⁴, Shinya Toyokuni⁵, Yusaku Nakabeppu¹ (1.Div. of Neurofunc. Genomics, Med. Inst. of Bioreg., Kyushu Univ., 2.Dept. of Agi. Sci. Phar., Fac. of Dent. Sci., Kyushu Univ., 3.Dept. of Physiol., Niho Univ. Schl. of Dent., 4.Dept. of Phar., Fact. of Pharm. Sci., Yasuda Womens Univ., 5.Dept. of Pathol. Biolog. Resp., Grad. Sch. Med., Nagoya Univ.)

ITPA, epilepsy, depolarization, encephalopathy