[3P-0468] Down-regulation of protein translation by OAS1 missense mutants and the pathogenesis of human OAS1 related pulmonary alveolar proteinosis with hypogammaglobulinemia.

〇Tsubasa Okano¹, Kento Inoue¹, Eri Kumaki-Matsumoto¹, Shinichiro Nakada², Makoto Otsu³, Kohsuke Imai¹, Hirokazu Kanegane¹, Tomohiro Morio¹ (1.Dept. of Pediatrics and Developmental Biology, TMDU., 2.Dept. of Bioregulation and Cellular Response, Osaka Univ., 3.Dept. of Transfusion and Cell Transplantation, Kitasato Univ.)

OAS1, Hypogammaglobulinemia, Pulmonary alveolar proteinosis, Immunodeficiency, Translation