In vivo suppression of pancreatic tumour by degradation of mutated KRAS using CANDDY technology

Satoshi Imanishi; Lijuan Huang; Shoko Itakura; Makoto Jitsuoka; Megumi Saito; Megumi Tsukamoto; Masamichi Ishizaka; Etsuko S. Miyamoto

[3P-0633] In vivo suppression of pancreatic tumour by degradation of mutated KRAS using CANDDY technology

〇Satoshi Imanishi¹, Lijuan Huang¹, Shoko Itakura², Makoto Jitsuoka^1,3, Megumi Saito^1,3, Megumi Tsukamoto^1,3, Masamichi Ishizaka^1,3, Etsuko S. Miyamoto^1,2,3 (1.EM-S. Mol. Med. Sci. Lab., Tokyo Univ. of Sci., 2.Res. Inst. for Biomed. Sci., Tokyo Univ. of Sci., 3.R&D Dep., FuturedMe Inc.)

Target protein degradation, CANDDY, KRAS mutation, Undruggable target, Chemical knockdown

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The 42nd Annual Meeting of the Molecular Biology Society of Japan

[3P-0633] In vivo suppression of pancreatic tumour by degradation of mutated KRAS using CANDDY technology

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