[4P-0101] Alterations in the RNA polymerase IIo ubiquitination cause TC-NER defect and Cockayne syndrome-like premature aging phenotype in mice

〇Yuka Nakazawa¹, Yuichiro Hara¹, Yasuyoshi Oka¹, Okiru Komine², Diana van den Heuvel³, Chaowan Guo¹, Yasukazu Daigaku⁴, Mayu Isono¹, Yuxi He¹, Mayuko Shimada¹, Kana Katoh¹, Nan Jia¹, Satoru Hashimoto¹, Yuko Kotani⁵, Yuka Miyoshi², Miyako Tanaka⁶, Akira Sobue², Norisato Mitsutake⁷, Takayoshi Suganami⁶, Akio Masuda⁸, Kinji Ohno⁸, Shinichiro Nakada⁹, Tomoji Mashimo⁵, Koji Yamanaka², Martijn S. Luijsterburg³, Tomoo Ogi¹ (1.Dept. of Genet., RIeM, Nagoya Univ., 2.Dept. of Neurosci. & Pathobiol., RIeM, Nagoya Univ., 3.Dept. of Hum. Genet., LUMC, 4.Frontier Res. Instit. for Interdiscip. Sci., Tohoku Univ., 5.Inst. of Experi. Animal Sci., Grad. Sch. of Med., Osaka Univ., 6.Dept. of Mol. Med. and Metab., .RIeM, Nagoya Univ., 7.Dept. of Rad. Med. Sci., Atom. Bomb Dis. Inst., Nagasaki Univ., 8.Div. of Neurogenet., Cent. for Neuro. Dis. & Canc., Nagoya Univ. Grad. Sch. of Med., 9.Dept. of Bioreg. & Cellul. Resp., Grad. Sch. of Med., Osaka Univ.)

DNA repair, transcription, NER, TC-NER