[4P-0592] Metalloprotease Nardilysin controls heart rate through the transcriptional regulation of ion channels critical for sinus automaticity

〇Mikiko Ohno¹, Hiroshi Matsuura², Kiyoto Nishi³, Takeru Makiyama⁴, Yasuhiko Kojitani⁴, Hirotaka Iwasaki¹, Shintaro Matsuda⁴, Eiichiro Nishi¹ (1.Dept. Pharma., Grad.Sch. of Med.,SUMS, 2.Dept. Physiol., Grad.Sch. of Med.,SUMS, 3.Dept. Anesthe., Grad.Sch. of Med.,Washington, U.S.A, 4.Dept. Cardiovasc., Grad.Sch. of Med.,Kyoto U.)

bradycardia, heart rate, ion channel, sinus automaticity, protease