2:05 PM - 2:35 PM

[4W-10-5] Autistic-like Behaviors and Atypical Brain Connectivity in Genetically Engineered SHANK3 Mutant Macaques Via CRISPR/Cas9

〇Zhou Yang^1,3,11, Jitendra Sharma^6,7,8, Qiong Ke⁴, Rogier Landman^3,9, Jingli Yuan², Hong Chen⁴, David Hayden¹⁰, Johan FisherIII¹⁰, Mingqing Jiang¹, Tomomi Aida³, Zhonghua Lu¹, Liping Wang¹, Sheeba Anteraper^3,5, Mriganka Sur^5,6,7, Huihui Zhou¹, Peng Xiang⁴, Robert Desimone^3,5, Guoping Feng^3,5,9, Shihua Yang ² (1.Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China, 2.College of Veterinary Medicine, South China Agricultural Universit, China, 3.McGovern Institute for Brain Research, Massachusetts Institute of Technology, USA, 4.Center for Stem Cell Biology and Tissue Engineering, Sun Yat-Sen University, China, 5.Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 6.Picower Institute for Learning and Memory, Massachusetts Institute of Technology, 7.Simons Center for the Social Brain, Massachusetts Institute of Technology, 8.Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 9.Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, 10.Computer Science and Artificial Intelligence Laboratory, MIT, 11.Montreal Neurological Institute, McGill University, Canada)

Autism , NHP Model, SHANK3 Mutation, CRISPR/Cas9, Germline Transmission