[3P-0119] Replication Stress Arisen by Radiation Leads to Genomic Destabilization and Clonal Evolution of Cells Abrogated their Defense Systems

〇Mai Hyodo^1,2, Yusuke Matsuno^1,3, Yasunori Horikoshi⁴, Satoshi Tashiro⁴, Hidetaka Torigoe³, Yasufumi Murakami², Ken-ichi Yoshioka¹ (1.Div. Carcin. Can. Pre., Natl. Cancer Ctr. Res. Inst., 2.Dept. of Biol. Sci. & Technol., Tokyo Univ. of Sci., 3.Dept. Appl. Chem., Fac. Sci., Tokyo Univ. of Sci, 4.Dept. of Cell. Biol., Res. Inst. for Rad. Biol. ＆ Med., Hiroshima Univ)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[3P-0120] DNA repair pathway after heavy-ion irradiation in mammalian cells

〇Masako Izumi¹, Tomoko Abe¹ (1.Accel. Appl. Res. Div., Accel. Sci., RIKEN)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[3P-0121] Differences in DNA damage response to high-LET ionizing radiation between human and rodent cells.

〇Takanori Katsube¹, Masahiro Murakami¹, Qiang Liu², Yi Xie³, Bing Wang¹ (1.NIRS, QST, 2.IRM, CAMS, China, 3.IMP, CAS, China)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[3P-0122(3PW-04-4)] The impact of DSB formation and Exo1-dependent processing of ssDNA gap intermediates during NER in UV-irradiated quiescent cells

〇Mitsuo Wakasugi¹, Yuko Miyaguchi¹, Hideki Tanaka¹, Risa Takeda¹, Takuma Kusunoki¹, Erika Sugita¹, Misato Yamagishi¹, Rimi Ishii¹, Tsukasa Matsunaga¹ (1.Inst. of Med., Pharma. and Health Sci., Kanazawa Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[3P-0123] Analysis of DNA structure that regulates mismatch-repair-dependent anti-recombination

〇Satoru Kouda¹, Satomi Oda², Aya Sakazume¹, Tatsuro Takahashi³ (1.Kyushu Univ., 2.Osaka Univ., 3.Kyushu Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[3P-0124] The anti-recombination reaction mediated by the mismatch repair system involves the accumulation of recombination intermediates containing single-stranded DNA regions

〇Aya Sakazume¹, Satomi Oda ², Satoru Koda¹, Tatsuro Takahashi³ (1.Grad. Sch. of Systems Life Sciences., Kyushu Univ., 2.Dept. of Biol. Sci., Grad. Sch. of Sci., Osaka Univ., 3.Dept. of Biol. Sci., Grad. Sch. of Sci., Kyushu Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[3P-0125(2PW-04-5)] Reconstitution of a chromatin-remodeling reaction that facilitates post-replicative DNA mismatch repair

Riki Terui¹, 〇Tatsuro Takahashi¹ (1.Fac. of Sci., Kyushu Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[3P-0126] Biochemical analysis of the clamp mediated mismatch repair function of NucS

〇Wakana Hara¹, Itaru Numata¹, Norihiko Takemoto², Masayuki Su'etsugu¹ (1.Dept. of Life., Col. of Sci., Rikkyo Univ., 2.Path. Micro., Res. Ins., NCGM)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[3P-0127] Possible end resection after double-strand cleavage by EndoMS, the damaged base specific endonuclease.

〇Wataru Mine¹, Takeshi Yamagami¹, Tomoyuki Numata¹, Sonoko Ishino¹, Yoshizumi Ishino¹ (1.Grad. Sch. of Bioresource & Bioenviron. Sci., Kyushu Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[3P-0128] Functional analysis of 8-Oxoguanine glycosylase found as an interaction factor with Endonuclease MS, the archaeal mismatch repair enzyme.

〇Takahiro Ichikawa¹, Takuya Sasaki¹, Takeshi Yamagami¹, Tomoyuki Numata¹, Sonoko Ishino¹, Yoshizumi Ishino¹ (1.Grad. Sch. of Bioresource & Bioenviron. Sci., Kyushu Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan