[4P-0466] A mechanism of region-specific neocortical overgrowth relevant to autism spectrum disorder

〇Nobuto Watanabe¹, Daichi Kawaguchi¹, Yukiko Gotoh¹ (1.Laboratory of Molecular Biology, Graduate School of Pharmaceutical Sciences, The University of Tokyo)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0467] Physical exercise increases extracellular vesicles circulating in blood

〇Akiko Takeda¹, Toshihide Takeuchi¹, Eiko N Minakawa², Keiji Wada², Yoshitaka Nagai¹ (1.Dept. Neurotherapeutics, Grad. Sch. of Med., Osaka Univ., 2.Dept. Degen. Neurol. Dis., Natl. Inst. of Neurosci., Natl. Ctr. of Neurol. and Psychiat.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0468] Role of hippocampal IRS1 serine phosphorylation in memory decline

〇Wei Wang¹, Daisuke Tanokashira¹, Yusuke Fukui¹, Megumi Maruyama¹, Chiemi Kuroiwa¹, Takashi Saito², Takaomi C. Saido², Akiko Taguchi¹ (1.Dept. of Integr. Aging Neurosci., NCGG, 2.Lab. for Proteolytic Neurosci., RIKEN CBS)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0469] Effects of tiose phosphate isomerase on Amyloid-beta production causing Alzheimer's disease

〇Mitsu Iwasaki¹ (1.Dept.of Human Health Sci, Grad.Sch.of Med.,Univ.of kyoto)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0470] Disturbed glutamate signaling in AD hippocampus revealed by an integrated analysis of altered expression profiles of genes in both human and mouse brains with Alzheimer's disease pathology

〇Nona Abolhassani¹, Masaaki Hokama¹, Daisuke Saitou², Masahiro Shijo³, Takashi Saito⁴, Takaomi C. Saido⁵, Mikita Suyama², Toru Iwaki³, Yutaka Kiyohara⁶, Yusaku Nakabeppu¹ (1.Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 2.Division of Bioinformatics, Research Center for Systems Immunology, Medical Institute of Bioregulation, Kyushu University, 3.Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, 4.Section of Neurocognitive Science, Graduate School of Medical Sciences, Nagoya City University, 5.Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 6.Hisayama Research Institute for Lifestyle Diseases)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0471] Deficiency of base excision repair enzyme, OGG1 or MUTYH alters activation status of microglia, amyloid-beta burden, and behavior pattern in App^NL-G-F knock-in mouse model of Alzheimerʼs disease

〇Yuri Mizuno¹, Abolhassani Nona¹, Mazzei Guianfranco¹, Takashi Saito^2,3, Takaomi C. Saido³, Yusaku Nakabeppu¹ (1.Div. Neurofunctional Genomics, Med. Inst. Bioreg., Kyushu Univ., 2. Dept. Neurocognitive Sci., Grad. Sch. Med. Sci., Nagoya City Univ. , 3.Lab. Proteolytic Neuroscience, RIKEN Center for Brain Sci. )

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0472] Development of cytotoxicity measurement method by Aβ42 in consideration of conformational change

〇Ayumi Nakatani¹, Marf M. Akbor², Hiroki Nakayama¹, Nobuyuki Kurosawa², Masaharu Isobe² (1.Grad. Sch. of Sci. & Eng. for Education, Univ. of Toyama, 2.Grad. Sch. of Sci. & Eng. for Research, Univ. of Toyama)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0473] Characteristic features of new Alzheimer's disease model mouse that express amyloid β oligomer intraneuronally

〇Tomoyo Ochiishi¹, Masami Kaku², Kazuyuki Kiyosue¹, Motomichi Doi¹, Tatsuhiko Ebihara¹ (1.Biomedical Res. Inst., AIST, 2.Faculty of Health and Sci., Uekusa Gakuen Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0474] Analysis of splicing regulatory factors for CD33, a risk gene for Alzheimer's disease.

〇Yuka Honda¹, Motoaki Yanaizu¹, Yoshihiro Kino¹, Jun-ichi Satoh¹ (1.Dept.of Life.Pharm.Sci.,Grad.Sch.of Pharm.,Univ.of Meiji Pharmaceutical )

The 42nd Annual Meeting of the Molecular Biology Society of Japan

[4P-0475] Regulatory mechanisms of species-specific alternative splicing of TREM2, a risk gene for Alzheimer's disease.

〇Motoaki Yanaizu¹, Yoshihiro Kino¹, Jun-ichi Satoh¹ (1.Dept.of Bioinformatics and Molecular Neurophathology, Meiji Pharmaceutical Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan