[1PW-13-5] Replication stress triggers microsatellite destabilization and hypermutation, leading to clonal evolution

〇Ken-ichi Yoshioka¹ (1.Div. of Carcino. and Can. Prev., Natl. Cancer Center Res. Inst.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Tue. Dec 3, 2019 5:00 PM - 5:20 PM

[1PW-13-6] ATR-dependent response to DNA replication stress during tumor development.

〇Bunsyo Shiotani¹ (1.National Cancer Center Research Institute)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Tue. Dec 3, 2019 5:20 PM - 5:40 PM

[1PW-13-7] Replication stress: cause, consequence, and application for cancer treatment

〇Masatoshi Fujita¹, Nozomi Sugimoto¹, Kazumasa Yoshida¹ (1.Dept. Cell. Biochem., Grad. Sch. Pharm. Sci., Kyushu Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Tue. Dec 3, 2019 5:40 PM - 6:00 PM

[1PW-13-8(4P-0549)] Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor

Kenichi Iwai^1,2,7, Tadahiro Nambu¹, Ryo Dairiki¹, Momoko Ohori¹, JIe Yu², Krissy Burke², Masamitsu Gotou³, Yukiko Yamamoto¹, Shunsuke Ebara¹, Sachio Shibata¹, Ryosuke Hibino¹, Satoru Nishizawa¹, Tohru Miyazaki¹, Misaki Homma¹, Yuya Oguro¹, Takashi Imada¹, Nobuo Cho¹, Noriko Uchiyama⁴, Akifumi Kogame⁵, Toshiyuki Takeuchi⁵, Osamu Kurasawa¹, Kazunori Yamanaka³, Huifeng Niu⁶, 〇Akihiro Ohashi^1,2,7 (1.Onc. DDU, Takeda Pharmaceutical Company Limited, 2.Onc. DDU, Takeda Pharmaceuticals International Co., 3.InteRL Lab., Takeda Pharmaceutical Company Limited, 4.Biomol. Res. Lab., Takeda Pharmaceutical Company Limited, 5.DMPK Res. Lab., Takeda Pharmaceutical Company Limited, 6.Translational & Biomarker Res., Takeda Pharmaceuticals International Co., 7.Div. Translational Genomics, EPOC, National Cancer Center)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Tue. Dec 3, 2019 6:00 PM - 6:15 PM

[1PW-14-1] Data Science for Multicellular Spatiotemporal Analysis

〇Teppei Shimamura¹ (1.Dev. Systems Biol., Nagoya Univ. Grad. Sch. Med.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Tue. Dec 3, 2019 3:45 PM - 4:05 PM

[1PW-14-2(1P-0634)] Global alignment of time-series single-cell RNA-seq data for comparing complex cell fates

〇Yuki Kato^1,2, Reiichi Sugihara², Tomoya Mori³, Yukio Kawahara^1,2 (1.Grad. Sch. of Med., Osaka Univ., 2.Fac. of Med., Osaka Univ., 3.ICR, Kyoto Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Tue. Dec 3, 2019 4:05 PM - 4:25 PM

[1PW-14-3] Utilizing enhancer genetics and omics analyses to understand cancer-host interaction

〇Shinpei Kawaoka¹ (1.Kyoto University)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Tue. Dec 3, 2019 4:25 PM - 4:45 PM

[1PW-14-4] Multi-Omics of 4D-Nucleome induced by inflammatory cytokine

〇Yasuharu Kanki¹, Yoshiki Higashijima^1,2, Yusuke Matsui³, Teppei Shimamura³, Yohei Abe⁵, Shuichi Tsutsumi⁴, Glass K. Christopher⁵ (1.Isotope Science Center, Univ of Tokyo, 2.Dept. of Bio-info Phamacol., Tokyo Medical and Dental Univ, 3.Dev. Systems Biol., Nagoya Univ. Grad. Sch. Med., 4.Dev Genome Science, LSBM, RCAST, Univ of Tokyo, 5.Dept of Mol Medicine, UCSD)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Tue. Dec 3, 2019 4:45 PM - 5:05 PM

[1PW-14-5] Landscape and biological/clinical relevance of multiple mutations in oncogenes

〇Keisuke Kataoka¹ (1.Natl. Cancer Cent. Res. Inst., Div. Mol. Oncol.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Tue. Dec 3, 2019 5:05 PM - 5:25 PM

[1PW-14-6] Translational regulation of cancer metabolism by the mTOR signaling pathway

〇Masahiro Morita¹, Sakie Katsumura¹, Nahum Sonenberg² (1.Dept. of Mol. Med. and Barshop Inst. for Longevity and Aging Studies, Univ. of Texas Health Sci. Ctr. San Antonio, 2.Dept. of Biochem. and Goodman Cancer Research Centre, McGill Univ.)

The 42nd Annual Meeting of the Molecular Biology Society of Japan |Tue. Dec 3, 2019 5:25 PM - 5:45 PM