9:23 AM - 9:41 AM

[1AW-03-2] Induction of an Alternative mRNA 5' Leader Enhances Translation of the Ciliopathy Gene Inpp5e and Resistance to Oncolytic Virus Infection

Huy-Dung Hoang¹, Tyson E Graber², Jian-Jun Jia³, Nasana Vaidya³, Victoria H Gilchrist¹, Xiao Xiang⁴, Wencheng Li⁵, Kyle N Cowan⁶, Christos G Gkogkas⁷, Maritza Jaramillo⁸, Seyed Mehdi Jafarnejad⁹, ○Tommy Alain¹⁰ (1.Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada, 2.Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada; Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, QC H3A 1A3, Canada, 3.Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada, 4.Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada, 5.Department of Biochemistry and Molecular Biology, Rutgers New Jersey Medical School, Newark, NJ 07101, USA, 6.Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada; Department of Surgery, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H 8L1, Canada, 7.Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK, 8.INRS Institut Armand-Frappier Research Centre, Laval, QC H7V 1B7, Canada, 9.Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast BT9 7AE, UK, 10.Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada)

ribosome profiling, translation, uORF