[1LBA-039] Fgf10-CRISPR mosaic mutants demonstrate the gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung

Munenori Habuta¹, Akihiro Yasue², Ken-ichi T. Suzuki^3,4, Hirofumi Fujita¹, Keita Sato¹, Hitomi Kono¹, Ayuko Takayama⁴, Tetsuya Bando¹, Satoru Miyaishi⁵, Seiichi Oyadomari⁶, Eiji Tanaka², ○Hideyo Ohuchi¹ (1.Dept. of Cytol. & Histol., Grad. Sch. of Med., Dent. & Pharm. Sci., Okayama Univ., 2.Dept. of Orthod.& Dentofac., Inst. of Biomed., Sci., Tokushima Univ. Grad. Sch., 3.Dept. of Math. & Life Sci., Hiroshima Univ., 4.Center for Dev. New Model Organisms, NIBB, 5.Dept. of Legal Med., Grad. Sch. of Med., Dent. & Pharm. Sci., Okayama Univ., 6.Div. of Mol. Biol., Inst. of Advanced Med. Sci., Tokushima Univ.)

Fibroblast growth factor 10, Fgf10, somatic mosaicism, limb development, lung development