Alternative splicing of REST through SRRM4 by a gapmer antisense oligonucleotide causes the cell death of neuroendocrine prostate cancer

○Misa Yoshida, Itsuki Tsuji, Keishiro Mishima, Satoshi Obika, Masahito Shimojo

[1LBA-058] Alternative splicing of REST through SRRM4 by a gapmer antisense oligonucleotide causes the cell death of neuroendocrine prostate cancer

○Misa Yoshida¹, Itsuki Tsuji¹, Keishiro Mishima¹, Satoshi Obika¹, Masahito Shimojo¹ (1.Osaka Univ. Grad. Sch. Pharm. Sci.)

antisense oligonucleotide (ASO), SRRM4 (Serine/Arginine Repetitive Matrix 4), neuroendocrine prostate cancer (NEPC), REST (RE1-silencing transcription factor)

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The 43rd Annual Meeting of the Molecular Biology Society of Japan

[1LBA-058] Alternative splicing of REST through SRRM4 by a gapmer antisense oligonucleotide causes the cell death of neuroendocrine prostate cancer

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