[1P-0136] GALECTIN-3 BINDING TO T ANTIGEN DIRECTLY MODULATES WNT SIGNALING VIA FRIZZLED-5 ENDOCYTOSIS IN MOUSE EMBRYONIC STEM CELLS

○Federico Pecori¹, Yoshihiro Akimoto², Hisatoshi Hanamatsu³, Jun-ichi Furukawa³, Yasuro Shinohara⁴, Yuzuru Ikehara⁵, Shoko Nishihara^1,6 (1.Laboratory of Cell Biology, Department of Bioinformatics, Graduate School of Engineering, Soka University, 1-236 Tangi-machi, Hachioji, Tokyo 192-8577, Japan, 2.Department of Anatomy, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan, 3.Department of Advanced clinical glycobiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan, 4.Department of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, Aichi 463-8521, Japan, 5.Department of Molecular and Tumor Pathology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan, 6.Glycan & Life System Integration Center (GaLSIC), Faculty of Science and Engineering, Soka University, 1-236 Tangi-machi, Hachioji, Tokyo 192-8577, Japan)

Wnt signaling pathway, C1GalT1, Glycosylation, Galectins, Pluripotency