[1P-0146] TPA-induced Degradation Mechanisms of PDCD4, a Tumor Suppressor, in Hepatocellular Carcinoma

○MD MANIRUJJAMAN¹, Iwata Ozaki ^1,2, Yuzo Murata³, Hiroshi Hamajima^1,4, Jinghe Xia¹, Rasheda Perveen¹, Hirokazu Takahashi¹, Keizo Anzai¹, Sachiko Matsuhashi¹ (1.Department of Internal Medicine, Saga Medical School, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan., 2.Health Administration Centre, Saga Medical School, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan., 3.Department of Anatomy and Physiology, Saga Medical School, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan., 4.Saga Food & Cosmetics Laboratory, Division of Research and Development Promotion, Saga Regional Industry Support Center, 114 Yaemizo, Nabeshima-machi, Saga 849-0932, Japan.)

PDCD4, Proteasome, PKC, Tumor promoter, TPA, EGF