[1P-0379] Establishment of exon-humanized mouse model for familial amyloidotic polyneuropathy optimal to develop a new therapy

○Seika Li^1,2, Hideki Kanazashi³, Hironori Katoh³, Yoshimi Tokashiki³, Rie Fujikawa³, Ayaka Okagaki³, Sho Katoh³, Kenta Kojima³, Kyoko Haruna³, Naoko Matsusihita³, Haruko Kumamogoh³, Shingo Shinagawa³, Tomo-o Ishikawa³, Kenichi Yamamura^2,3 (1.Dept. of Histol. Embryos., Harbin Med. Univ., 2.Institute of Resource Dev. and Analysis, Kumamoto Univ., 3.Transgenic, Inc.)

humanized mouse, transthyretin, genome editing, familial amyloidotic polyneuropathy