[1P-0380] Studies on the fully human antibody-producing mice (1): Repertoire analysis of human immunoglobulin locus on the artificial chromosome in the mouse

○Hiroyuki Satofuka¹, Takashi Moriwaki^1,2, Satoshi Abe³, Hiroshi Tanaka³, Kayoko Morimoto³, Kyoutarou Yamazaki⁴, Kazuma Tomizuka⁵, Mitsuo Oshimura³, Yasuhiro Kazuki^1,2 (1.CERC, Univ. of Tottori, 2.Dept. of Life Sci., Sch. of Med., Univ. of Tottori, 3.Trans Chromosomics Inc., 4.Dept. of Reg. Med. Biofunc., Grad. Sch. of Med. Sci., Univ. of Tottori, 5.Dept. of Life Sci., App. Life Sci., Tokyo Univ. of Pharm. Life Sci.)

Fully human antibody-producing mice, Artificial chromosome, Trans-chromosomics technology , Human immunoglobulin gene, V(D)J rearrangement and somatic hypermutation