[1P-0389] Mechanical cues of polyrotaxanes control osteogenic differentiation for adjunct treatment of craniosynostosis

○Shohei Yanagisawa^1,2, Sachiko Iseki¹, Rajendran Arun Kumar¹, Nobuhiko Yui⁸, Yoshinori Arisaka⁸, Kenichi Nakahama⁹, Hiroyuki Harada², Koichi Ueda³, Takashi Nuri³, Atsuko Harada⁶, Shinji Kobayashi⁵, Tadashi Kaname⁴, Youichirou Ninomiya⁷ (1.Dept. of Molecular Craniofacial Embryology,Grad. Sch. of Medical and Dental sciences, Tokyo Medical and Dental University, 2.Oral and Maxillofacial Surgery, Dept. of Oral Restitution, Div. of Oral Health Sciences,Grad. Sch. of Medical and Dental sciences, Tokyo Medical and Dental University, 3.Dept.of Plastic and Reconstructive Surgery,OMC, 4.Dept.of Genomic medicine,NCCHD, 5.Dept.of Plastic Surgery,KCMC, 6.Dept.of Pediatric Neuro surgery,Takatsuki General Hospital, 7.Research Centre for Medical Bigdata,NII, 8.Dept. of Organic Biomaterials,Inst. of Biomaterials and Bioengineering,Grad. Sch. of Medical and Dental sciences, Tokyo Medical and Dental University, 9.Dept. of Cellular Physiological Chemistry,Grad. Sch. of Medical and Dental sciences, Tokyo Medical and Dental University)

craniosynostosis, osteoblast, polyrotaxane, differentiation