10:20 AM - 10:40 AM

[2AW-13-5] Novel protein-uptake pathway in lysosomes required for neuromuscular homeostasis

○Yuuki Fujiwara¹, Viorica Raluca Contu¹, Chihana Kabuta¹, Megumu Ogawa², Hiromi Fujita¹, Hisae Kikuchi¹, Ryohei Sakai¹, Katsunori Hase¹, Mari Suzuki³, Ikuko Koyama-Honda⁴, Michio Inoue^2,5, Yasushi Oya⁶, Yukiko U. Inoue⁷, Takayoshi Inoue⁷, Ryosuke Takahashi⁸, Ichizo Nishino^2,5, Keiji Wada¹, Satoru Noguchi^2,5, Tomohiro Kabuta¹ (1.Dept. of Degener. Neurol. Dis., Natl. Inst. of Neurosci., Natl. Centr. of Neurol. and Psy., 2.Dept. of Neuromus. Res., Natl. Inst. of Neurosci., Natl. Centr. of Neurol. and Psy., 3.Dept. of Sens. and Mot. Syst., Tokyo Met. Inst. of Med. Sci., 4.Dept. of Biochem. and Mol. Biol., Grad. Sch. and Facul. of Med., Univ. of Tokyo, 5.Med. Genom. Centr., Natl. Centr. of Neurol. and Psy., 6.Dept. of Neurol., Natl. Centr. Hosp., Natl. Centr. of Neurol. and Psy., 7.Dept. of Biochem. and Cellular Biol., Natl. Inst. of Neurosci., Natl. Centr. of Neurol. and Psy., 8.Dept. of Neurol., Grad. Sch. of Med., Kyoto Univ.)

lysosome, protein translocation, protein degradation/proteolysis, DUMP, neuropathy/myopathy