Cigarette smoke extract induces the release of nuclear and mitochondrial DNA into the cytosol and chronic inflammation via activation of the cGAS-STING pathway

○Keitaro Ueda, Mari Ishida, Chiemi Sakai, Masao Yoshizumi, Takafumi Ishida

[2LBA-064] Cigarette smoke extract induces the release of nuclear and mitochondrial DNA into the cytosol and chronic inflammation via activation of the cGAS-STING pathway

○Keitaro Ueda¹, Mari Ishida¹, Chiemi Sakai¹, Masao Yoshizumi¹, Takafumi Ishida² (1.Dept of Cardio Physio & Med, Grad Sch of Biomed & Health Sci, Hiroshima Univ., 2.Dept of Cardio Med, Sch of Med, Fukushima Med Univ.)

DNA damage, mitochondrial DNA, cytosolic DNA, inflammation, tobacco

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The 43rd Annual Meeting of the Molecular Biology Society of Japan

[2LBA-064] Cigarette smoke extract induces the release of nuclear and mitochondrial DNA into the cytosol and chronic inflammation via activation of the cGAS-STING pathway

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