Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization

○Kazuki Matsumura, Takushi Shimomura, Yoshihiro Kubo, Takayuki Oka, Naohiro Kobayashi, Shunsuke Imai, Naomi Yanase, Madoka Akimoto, Masahiro Fukuda, Mariko Yokogawa , Kazuyoshi Ikeda, Jun-ichi Kurita, Yoshifumi Nishimura , Ichio Shimada, Masanori Osawa

[2P-0041] Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization

○Kazuki Matsumura¹, Takushi Shimomura², Yoshihiro Kubo², Takayuki Oka³, Naohiro Kobayashi^4,5, Shunsuke Imai⁶, Naomi Yanase¹, Madoka Akimoto¹, Masahiro Fukuda¹, Mariko Yokogawa ¹, Kazuyoshi Ikeda¹, Jun-ichi Kurita⁷, Yoshifumi Nishimura ⁷, Ichio Shimada⁶, Masanori Osawa¹ (1.Grad. Sch. Pharm. Sci., Keio Univ., 2.Dept. Mol. Cell. Physiol., NIPS, 3.Nanion Technologies Japan, 4.IPR, Osaka Univ., 5.RSC, RIKEN, 6.Grad. Sch. Pharm. Sci., Univ. of Tokyo, 7.Grad. Sch. Med. Life Sci., Yokohama City Univ.)

Gating-modifier toxin, APETx1, Voltage-gated potassium channel, hERG, Voltage-sensing domain

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The 43rd Annual Meeting of the Molecular Biology Society of Japan

[2P-0041] Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization

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