10:35 AM - 10:55 AM

[3AW-11-6] Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns

○Jagat K. Chhipi Shrestha^1,2, Tilman Schneider-Poetsch¹, Takehiro Suzuki³, Mari Mito⁴, Khalid Khan¹, Naoshi Dohmae³, Shintaro Iwasaki^4,5, Minoru Yoshida^1,2,6 (1.Chem. Gen. Res. Gr., RIKEN CSRS, 2.Dept. of Biotech., Grad. Sch. of Agr. and Life Sci., Univ. of Tokyo, 3.Biomol. Char. Unit, Tech. Platf. Div., RIKEN CSRS, 4.RNA Sys. Biochem. Lab., RIKEN CPR, 5.Dept. of Comp. Biol. and Med. Sci., Grad. Sch. of Front. Sci., Univ. of Tokyo, 6.Coll. Res. Ins. for Innovat. Microbio., Univ. of Tokyo)

Spliceostatin A, Intron, Proteotoxicity, Condensate