[3LBA-049] cGAS-nucleosome structure reveals the cGAS inactivation mechanism by nucleosomes

○Tomoya Kujirai¹, Christian Zierhut², Yoshimasa Takizawa¹, Ryan Kim², Lumi Negishi¹, Nobuki Uruma^1,3, Seiya Hirai^1,4, Hironori Funabiki², Hitoshi Kurumizaka^1,3,4 (1.IQB, Univ. of Tokyo, 2.Rockefeller Univ., 3.Grad. Sch. of Adv. Sci. and Eng., Waseda Univ., 4.Dept. of Biol. Sci, Grad. Sch. of Sci., Univ. of Tokyo)

cGAS, innate immune system, chromatin, nucleosome, cryo-EM